They are more equipped to handle the entry of a pathogen. Between these cells are tight junctions, like a barricade that prevents infections from getting through. But if those junctions break and an intruder gets in, immune cells (the T and B cells) arrive, which are active immune fighters. These cells are the snipers and our Navy SEALs. <a href=''>As</a> Harvard professor and pediatric gastroenterologist Dr Alessio Fasano says, The intestinal mucosa [gut] is the battlefield on which friends and foes need to be recognized and properly managed to find the ideal balance between tolerance and immune response. <a href=''>Normally,</a> when hostile bacteria and viruses come through our intestines, we have a tight junction barricade and this large cavalry to handle the enemy, and the body deals with it with hopefully few casualties. <a href=''>There</a> are certain illnesses, however, where the tight junctions break and allow the bloodstream to be exposed to abnormal bacteria or bacterial by-products. <a href=''>Those</a> abnormal by-products can then enter into the bloodstream and create an inflammatory response. <a href=''>Shane</a> is a man that finds his own apathy troubling, but fails to make any efforts whatsoever to fix his life. <a href=''>He</a> recognizes that his life's problems could be solved quite simply with proactive action, but he doesn't care enough to take any proactive action. <a href=''>For</a> instance, he clearly hates his job at his insurance company, Panopticon Insurance. <a href=''>If</a> you couldn't tell from how he spends his days at work every day, then you might need to read about his daily routine again. <a href=''>Sleeping</a> on toilets all day to the point of nerve damage in his legs, then stumbling drunk with numb legs to his desk, without bothering to shower or take care of his own health? <a href=''>He</a> clearly does not want to be there. <a href=''>Yet,</a> even with these clear facts, he struggles to simply quit and move on from this job he loathes. <a href=''>Here's</a> Shane describing this dilemma: <a href=''>I</a> just couldn't take working at Panopticon Insurance anymore. <a href=''>Changes</a> had to be made, but I didn't want to be the one to have to make them. <a href=''>At</a> the time of the disclosure, many experienced anger: anger for the pain to the other parent, anger for the embarrassment, but predominantly anger over their lives having been turned upside down. <a href=''>They</a> were often fearful of the financial ramifications. <br /><br /><a href=''>I</a> felt like I wanted to punch them. <a href=''>But</a> I just sat there. <a href=''>My</a> dad was going on about his being a sex addict and treatment and steps and other stuff that I couldn't care less about, and the wordbankruptcy' came up because at the time we were being sued, and that really struck a chord with me. What did that mean for me? Would I lose my chance to go to college? For many of the children we evaluated, the term sex addiction created a picture of their parent being a pervert or a child molester. They frequently found themselves in fear of a parent whom they had previously trusted. I felt sick, horrified. A short response can be handled by the Navy SEALs without too much difficulty. But with a prolonged assault, this inflammatory response triggers formation of an abundance of inflammatory cells that can get out of hand and attack different parts of the host body. An example of the leaky gut phenomenon is found in celiac disease, the study of which has been pioneered by Dr Alessio Fasano. People with celiac disease have an allergy to gluten, which is present in wheat, rye, and barley. When people with gluten allergy eat gluten, their bodies respond poorly. Over time, they develop symptoms of malabsorption because their guts are unable to absorb any useful food particles--the gut is too massively inflamed. They don't just manifest gut symptoms. Inflammation rages through their bodies. They develop diarrhea, abdominal pain, skin changes, and joint pain and can have neurologic manifestations. Note that gluten allergy is different from gluten sensitivity. I figured if I was drunk all the time I'd be even more obviously incompetent and they'd have no choice but to fire me. As bad as it was I couldn't bring myself to quit.

Quitting is too proactive, and it reflects poorly on a person's character. Nobody likes a quitter. I would always rather be a victim of circumstance. When a man would rather be a victim to his circumstances than proactively fix his situation, you know that he's pathetically apathetic. And sadly, so many of us can relate! Because, remember, It takes more than one kick in the pants to reverse a lifetime of unplanned apathy. As I've already referenced, Shane has many life revelations toward the end of the story, when he's being investigated by the police and there haven't been clear answers for Marlene's death. Here's Shane discussing his regrettable experiences in this new city: What are other people going to think? Can I be left home alone with him? Confusion was a predominant feeling the children experienced with the disclosure. I was only seven! I was too little to understand. And now we had to move and I had to leave my friends. That is what I understood. The last thing I needed was to feel different from other kids. I was really too young (eleven). I didn't know much about sex and it was foreign. The immune changes with gluten allergy associated with celiac disease is an autoimmune reaction. This reaction can cause damage to the lining of the intestines.

Gluten sensitivity can cause many symptoms, such as headache, joint pain, and fatigue, but sensitivity doesn't necessarily damage the intestinal lining. Dr Fasano and others have shown that when people with gluten allergy are exposed to gluten, the tight junctions between their intestinal cells become leaky. The doors to the insides of their gut open. An environmental trigger, such as wheat in the case of celiac disease, then comes through the door and creates an immune reaction. Immune complexes form which then destroy the villi. Once destroyed, these villi cannot contribute to digestion and cannot help shunt essential nutrients into the bloodstream. Immune complexes create systemic reactions. Fasano believes that some level of leaky gut is a good thing. There comes a time in every man's life when he wakes up drunk on the toilet and begins to doubt the choices he has made. And when that time comes at least twice a day, every day, something needs to be done. These are hard, entirely unspecific questions. And apathy has its own slow momentum. It doesn't like to be disturbed. No, it doesn't like to be disturbed. I'm sure you (the reader), have noticed this by now. Once apathy has a stranglehold of comfort on our life, it's quite difficult to rip it from its grasp. What Shane ultimately accepted about his life is that you do, in fact, need to rip the apathy. You need to murder apathy. I really couldn't imagine my dad doing the things he did and that was hard for me. This made my relationship with my dad very awkward when I didn't find it that way before.

I felt very uncomfortable being left alone with him. The children often became compliant or reached out to emotionally take care of their parent(s). Even when they knew what their parent did was not okay, they felt a need to be protective of one or both of their parents. I knew my dad was being forced to tell me. If he didn't tell me, my stepmother would have. She was really angry and was divorcing him. He was crying and so embarrassed. I didn't know what to do or feel--mostly I felt sorry for him. Most people have occasional intestinal permeability where the doors open for a short time. During that time, the immune system is exposed to foreign particles and learns to respond to them. But in celiac sufferers, the intestine is leaky for hours and the immune system becomes massively inflamed. As Fasano says, Friend or foe: when there is a fight, there is always collateral damage, ie, inflammation. Some environmental triggers can make one person have a leaky gut for hours while another person has a leaky gut for just minutes. We now know that a person must have a genetic predisposition to a certain sensitivity. We can't necessarily fix this predisposition because we get it from our parents. But it is only when the environmental trigger appears, however, that a person actually becomes sick. Then we can potentially eliminate the trigger, decrease the leaky gut, decrease inflammation, and treat the chronic disease. Fasano and others believe that many autoimmune diseases are affected by food sensitivities and changes in the microbiome at an early age. You need to pulverize it and pile drive apathetic behaviors into the ground. Completely decimate it.