How the TAME Study Works Overseen by the American Federation for Aging Research (AFAR), TAME is a six-year, double-blind, placebo-controlled trial in which we have enrolled a diverse population of about three thousand adults, ages sixty-five to eighty, who do not have diabetes but who have begun to contract age-related …

A week later, AFAR informed me that he believed in our research and wanted to contribute a significant amount to the study. Every time I hear about a new investor, it's music to my ears. Metformin Is the Tool, Not the Goal Installing insulation in your attic or weather stripping …

After the meeting, Robert Temple, deputy center director for clinical science for the FDA's Center for Drug Evaluation and Research, commented for Ron Howard's The Age of Aging, a documentary about the science of aging: Loss of muscle tone, dizziness, falling, dementia, loss of eyesight, all those things--to [approach] them …

Fortunately, we have AFAR as a partner. My history with AFAR goes back to 1996, when the field of aging studies was sparsely populated and the organization gave me my first grant, which allowed me to gather the data I needed to then get an NIH grant for much more …

Well, there are two answers. First of all, your people take less metformin than any other state. But there's really a much more important reason--your people are victims of the good food of Mississippi, this food you can't stop eating. Knowing that they can make a difference in their school …

Who's Going to Pay for All of This? We had thought that designing the study would be the hardest part of the battle. Once again, we were wrong. Stufft added, You have done so much to help the school help the environment and help the planet. This stance of service …

After the conference in Spain, the evidence in metformin's favor became overwhelming. In addition to the safety factor--metformin has sixty-plus years of safe use, compared with the unresolved safety issues of many other drugs that can target aging--new clinical trials reported significant reductions in the risk for type 2 diabetes …

We're also collecting data on common geriatric conditions, such as fractures and pneumonia, and syndromes, such as frailty and fall-related injuries. When TAME concludes, this information will be made available to the broad research community and health care providers to guide and accelerate the pace of applied geroscience. Although functional …

Saying, No, thank you, to a $10 million gift was not something that Hassy or I wanted to have on our records. We needed a miracle. And we got one. The average American produces about 4. Unless you compost or recycle it, waste goes into landfills. Garbage dumps take up …

CohBar is currently focusing on NASH with an analog to MOTS-C that is in a clinical study. Stay tuned for more good news to come as we move anticancer and antifibroptic therapy to clinical trials. As geroscientists continued researching aging and longevity, we were convinced that the biological processes that …

When we decided to form the company, we promised each other that we would not make the same mistakes that put 95 percent of biotech start-ups out of business. And while that success rate didn't sound promising, because we are both M. We also had the benefit of having served …

Such damage may be initiated in part when telomeres (DNA strands at the end of chromosomes) get shorter. Senescence: Len Hayflick has shown that there are limits to the number of times a cell can divide. When cells divide for the last time, their appearance and functions change, and these …

For the past few years, Jerry has devoted much of his time to his role as Bernice's caregiver. They moved into a continuing care center after she suffered a stroke, and as his son-in-law and a scientist studying SuperAgers, it's rewarding for me to see the determination he's able to …

I was skeptical, to say the least. Try doing due diligence on Mr Liu in China. There are millions of Mr Lius from China on the Web. My husband, who was getting something out of the car, said, Go the other way, then demonstrated how to rip it. Ethan shredded …

We were on our way to achieving our dream to make a drug that could protect against aging itself and all the diseases associated with it! And then the bottom fell out. A few months after we had received a total of $2. These days, the club is incredibly popular …

It's immune dysfunction that makes viruses like Coronavirus life-threatening to the elderly. After they have the virus for a few days their immune systems create an immunological storm that causes the clinical features that can lead to death. Rejuvenating the immune response may lower or eliminate this effect on the …

So he took a job as a controller with a trucking company that offered more opportunity, and he remained in the trucking industry until the early '80s--a career during which he achieved his goal of financial independence and negotiated with Teamsters president Jimmy Hoffa. You'd tell him beforehand what it …

But instead of being disoriented by our surprise visit, when we explained things to her, she would say something to the effect of This is so great, because I'm pleasantly surprised twice--when you call and when you arrive. Frieda died in 2008 at age 102. One of her siblings had …

She lived by her own rules, as her son Jerry Rubenstein (my father-in-law) attests. The poker games went on for years, and there was a game where she began laughing or giggling at the table and someone who was taking it too seriously criticized her for it, he says. So …

I mean, I called it unrealistic, but it was supported by her lifetime of experiences. Hand in hand with her optimism was a refusal to take things more seriously than necessary--a refusal to take on more stress than necessary. In that regard, she and Jerry--both participants in our study of …

While farmers markets are far from perfect, they're still a solid alternative to growing your own food. Purchasing a farm share in a community supported agriculture (CSA) program provides even more direct support to farmers. The CSA we participated in allowed us to choose which fruits and vegetables we wanted …

Talking about both resistance and resilience inspires young people. There are a lot of things wrong with the food system, Olugbala said. This is evidence that you don't have to just take it. We're in a space that is an actual point of resistance. Alternatives to Home and School Gardens …

Just participating in the process of growing helps kids realize how much work goes into producing their fruits and vegetables. They understand how hard it is to go from farm to plate, said Fisher. To see that food takes time, tending, sun, soil, water, and air is a pretty refreshing …

Since my own kids have been big enough to have opinions, I've worked with them to plan our garden. In the winter, we look at the seed catalog together and they make suggestions about what types of seeds to buy. Asking kids for their ideas and listening to their perspectives …

They may still swipe your tools, but at least you'll have extras. It's great if you can set aside a space for kids to do whatever they want. In our yard, we have a small raised bed that our kids plant and dig in. We've planted giant sunflowers with enough …

You can't win them all, I suppose. What to Know Start Small and Relatively Simple Over-ambition is one of the biggest killers of gardens. Whether it's a home, school, or community garden plot, start small. Sometimes what we see is that there's a lot of fear with people not knowing …

Children and families are more connected and are working together. Similarly, Nicholes said that both her home garden and the We Sow, We Grow community farm are places her family can spend time together without planned activities. I do think that in society, we're losing that ability to have togetherness …

Folks now realize that our space is a safe place for them to come and talk and be curious without feeling like they're being a burden on anyone, she said. For people to see folks smack-dab in the middle of the city, growing food, their curiosity gets the better of …

I've never seen spinach or lettuce ripped so thoroughly. Each time the salad spinner or glass jar came around, they put some serious muscle into it. As the kids prepped each ingredient, they tossed it into a big bowl, combining it into one giant salad. As we finished, the instructors …

Empowered by having real tools, the kids went to town. We next moved on to kale, the much-maligned hipster green. But we were going to do something a little different here. Do we eat flowers? When the kids looked confused, she said, We can eat these! Pick two yellow kale …

Having searched for flowers, it was time for us to plant our own. Gathering the kids around an empty patch of dirt, the instructor knelt down with a trowel. Just dig up a little bit of dirt, she said as she pushed some soil aside. Take a few flower seeds …

Often, lessons learned in the garden can extrapolate to the bigger picture of the ecosystem. Alethea Jo Mshar gardens with her three kids in rural Michigan. She said that gardening helps her children see the effects that people have on the natural world. it's the dog digging up plants or …

In a long-term garden project, there's even less immediate gratification. There's also something nice about gardening that it's kind of time released in terms of your experience of it, said Fisher, talking about his experience at Life Lab and his son's school garden. It's a different way to experience things …

In the Youth Garden's Green Ambassadors program for high school students, participants cook a meal each Friday for the entire staff with produce from the garden. Building Relationships and Service to Others With the food eaten and the program over, it was time to go home. But I still had …

The kids are interested in different varieties of tomatoes and ask questions about whether they're heat resistant or not--an essential characteristic during hot Chicago summers. She said, I'm loving the fact that the kids are thinking about their food in a different way. But also learning to love what they …

She saw the effects gardening had on the women: it helped them reduce their stress levels, develop more empathy, and manage their anger. A lot of them saw significant changes in themselves as a result of participating in the gardening project, she said. Many of the women applied the ideas …

But we had a workshop to get to. Not right now--afterwards, I promise, I said, hoping that I'd remember to follow up. He ran through the paths ahead of me. We passed by a huge painted monarch butterfly, groups of green plants, and a wooden insect hotel. The main gathering …

All of this sounded pretty damn amazing to me. Fortunately the Washington Youth Garden offers weekend workshops to local families. My kids got psyched for the workshop on pollinators. Our garden is fine, but someone else's garden with games and activities? As Slimey the worm from Sesame Street is three-year-old …

Handing each kid an empty egg carton, the instructor said, Find up to twelve different colors of flowers. Roaming the space, the kids kept a look out for a variety of colors. Among the green leaves, picking out purple, red, yellow, and white flowers took a keen eye and close …

Gardening is a holdover from my own childhood, when I spent hours upon hours messing around in the dirt. While my mom tended to her flowers, I gathered weeds to make magical potions. Entire worlds existed only in my head and backyard. As an adult I moved onto growing my …